US Molecular Molecular Imaging for Life

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• Posted 1 year ago
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Tags

• cardiology
• vasculitis
• PET/CT
• FDG

1. 

   v78q2zqd76fqfr
   Key Master
   Posted 1 year ago
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   Menezes LJ, Kotze CW, Hutton BF, Endozo R, Dickson JC, Cullum I, Yusuf SW, Ell PJ, Groves AM.

   Institute of Nuclear Medicine, University College Hospital, University College London, London, United Kingdom.

   We prospectively investigated the ideal imaging time to measure vascular uptake after injection of (18)F-FDG. METHODS: A total of 17 patients with atherosclerotic abdominal aortic aneurysm underwent dynamic abdominal PET/CT using 2-min frames between 45 and 53, 57 and 65, 115 and 123, and 175 and 183 min after injection of (18)F-FDG. For each period of dynamic imaging, vessel wall and lumen uptake were measured using the maximum standardized uptake value (SUVmax) and target-to-background ratio (TBR). RESULTS: No significant difference in TBR across all time points (repeated measures ANOVA, P = 0.206) was observed, despite a significant difference in aortic wall and lumen uptake with time (repeated measures ANOVA, P = 0.02 and P < 0.001, respectively). There was no significant difference between aortic wall uptake at 60 min (SUVmax, 2.15 +/- 0.11 SE) and 180 min (SUVmax, 1.99 +/- 0.18 SE) (paired t test, P = 0.367). There was a significant difference in lumen uptake at 60 min (SUVmax, 2.4 +/- 0.11 SE) and 180 min (SUVmax, 1.7 +/- 0.1 SE) (paired t test, P = 0.001). There was no significant difference in TBR between 60 min (0.91 +/- 0.03) and 180 min (1.01 +/- 0.06 SE) (paired t test, P = 0.131). With increasing delayed imaging, there was increasing variability (SE) in the SUVmax for the aortic wall and TBRs. CONCLUSION: There was no significant advantage in imaging at 3 h over 1 h after (18)F-FDG injection.

   http://www.ncbi.nlm.nih.gov/pubmed/19443587